This page is not found

Our most common searches

Here are some helpful links instead

Ooops, sorry the page you requested cannot be found.

Are you looking for:
Kenozole Cream (Ketoconazole) Kenozole general information What is Kenozole used for? Kenozole Cream 2% is used as a topical treatment for fungal infections of the skin and scalp, due to the Tinea fungus. Tinea is a dermatophyte fungus also known as ringworm. Tinea causes fungal infection in different parts of the body including ringworm of the foot, also known as Athlete's foot (tinea pedis), of the body (tinea corporis), of the groin (tinea cruris or jock itch), and of the scalp (tinea capitis). Kenozole Cream 2% is also used to treat infection by the yeast fungus Malassezia, which causes Pityriasis versicolor, characterised by flaky discoloured patches that appear on the chest and back and seborrhoeic dermatitis, a form of dermatitis or inflammation of the skin that affects mainly the scalp and face. Kenozole Cream 2% is also effective against infection with the yeast fungus Candida, which causes cutaneous candidiasis, characterised by itchy red rash on various parts of the body, usually in warm, moist creased areas of skin, like under the arms and in the groin. How does Kenozole work? Kenozole Cream 2% contains ketoconazole, a synthetic broad-spectrum antifungal that is used to treat a variety of fungal infections of the skin. Ketoconazole in Kenozole Cream 2% prevents growth of dermatophyte and yeast fungi by inhibiting the synthesis of ergosterol, an important component of fungal cell membrane that is not found in animal cells. This results in altering the permeability of the fungal cell membrane causing it to become weakened, so that the cell contents to leak out, which kills the fungus, preventing the infection from spreading and relieving symptoms caused by the fungal infection, including pain and inflammation. When used as a topical antifungal, no detectable ketoconazole enters the blood, reducing risk of systemic side effects. What does Kenozole contain? Kenozole Cream contains the active ingredient ketoconazole 2% (w/w), a synthetic broad-spectrum antifungal that is used to treat a variety of fungal infections. Treating fungal infections with Kenozole Kenozole Cream 2% contains ketoconazole, a synthetic broad-spectrum antifungal that is used to treat a variety of fungal infections due to dermatophyte fungus Tinea, known as ringworm and the yeast Candida. These infections include, ringworm of the foot, also known as Athlete's foot (tinea pedis), of the body (tinea corporis), of the groin (tinea cruris or jock itch), and of the scalp (tinea capitis). Malassezia is a yeast-like fungus that causes Pityriasis versicolor, characterised by flaky discoloured patches that appear on the chest and back and seborrhoeic dermatitis, a form of dermatitis or inflammation of the skin that affects mainly the scalp and face. Candida causes cutaneous candidiasis, characterised by itchy red rash on various parts of the body, usually in warm, moist creased areas of skin, like under the arms and in the groin. Ketoconazole in Kenozole Cream 2% prevents growth of dermatophyte and yeast fungi by inhibiting the synthesis of ergosterol, an important component of fungal cell membrane that is not found in animal cells. This results in altering the permeability of the fungal cell membrane causing it to become weakened, so that the cell contents to leak out, which kills the fungus, preventing the infection from spreading and relieving symptoms caused by the fungal infection, including pain and inflammation. What are the side effects of Kenozole? The most commonly reported side effects when using Kenozole Cream 2% include, burning sensation or irritation at the site of application, such as redness, pain and swelling; oily or dry scalp, mild hair loss. When should Kenozole not be used? You should not use Kenozole Cream 2% if you: are allergic to ketoconazole or any ingredients in Kenozole are pregnant or are breastfeeding, without discussion with your doctor How should Kenozole be used? You should apply your Kenozole Cream 2% to the affected area and rub gently into the skin once or twice daily depending on what you are being treated for and the severity of the infection. You should continue your course of treatment with Kenozole Cream for 2-6 weeks, depending on what you are being treated for and your doctor’s recommendation, until signs and symptoms of the infection has disappeared. Wash your hands to prevent spreading the infection and do not get the cream into your eyes. How long should you take Kenozole? You should continue your course of treatment with Kenozole Cream for 2-6 weeks, depending on what you are being treated for and your doctor’s recommendation. Missed dose of Kenozole If you miss a dose of Kenozole apply it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose. How should Kenozole be stored? You should store your Kenozole below 25°C in a cool dry place.
Hyphoral 200mg (Ketoconazole) Hyphoral general information What is Hyphoral used for? Hyphoral tablets 200mg are used to treat severe systemic fungal infections only in patients who cannot tolerate other treatments or where other treatments have failed and where the potential benefits are considered to outweigh the potential risks. Hyphoral tablets 200mg are used for systemic fungal infections caused by inhalation of the spores of a soil fungus that can affect internal organs and cause influenza-like illness with fever, cough, headaches, skin rash, and myalgia (muscle pain), such as coccidioidomycosis caused by Coccidioides immitis, Blastomycosis, caused by Blastomyces dermatitidis and histoplasmosis caused by Histoplasma capsulatum. Serious symptoms can develop including chronic lung infection and widespread infection reaching the bones, skin and urinogenital tract. Hyphoral 200 is also used to treat chromomycosis, caused by penetration of the skin by a thorn or splinter and infection by several different fungal species that spread slowly through the skin. Hyphoral tablets 200mg should not be used to treat fungal meningitis as the medication cannot penetrate into the nervous system. How does Hyphoral work? Hyphoral tablets 200mg contain ketoconazole, a synthetic broad-spectrum antifungal agent that specifically kills the fungus by inhibiting the synthesis of ergosterol, an important component of fungal cell membrane that is not found in animal cells. Ketoconazole in Hyphoral tablets 200mg weakens the fungal cell membrane, causing the cell contents to leak out which kills the fungus, preventing the infection from spreading and relieving symptoms caused by the fungal infection, including pain and inflammation. What does Hyphoral contain? Hyphoral tablets 200mg contain the active ingredient ketoconazole, a synthetic broad-spectrum antifungal used to treat severe systemic fungal infections. Treating systemic fungal infection with Hyphoral Hyphoral tablets 200mg contain ketoconazole, a synthetic broad-spectrum antifungal agent that is used to treat severe systemic fungal infections in patients who cannot tolerate other treatments or where other treatments have failed and where the potential benefits are considered to outweigh the potential risks. These infections include coccidioidomycosis, histoplasmosis and blastomycosis, which are all caused by inhalation of spores produced by soil fungi. Symptoms usually include influenza-like illness with fever, cough, headaches, skin rash, and myalgia (muscle pain), however, these infections can be difficult to treat and can affect internal organs causing serious symptoms including chronic lung infection and widespread infection reaching the bones, skin and urinogenital tract. Ketoconazole in Hyphoral tablets 200mg inhibits the synthesis of ergosterol, an important component of fungal cell membrane that is not found in animal cells, which weakens the fungal cell membrane, causing the cell contents to leak out which kills the fungus, preventing the infection from spreading. What are the side effects of Hyphoral? The most commonly reported side effects when taking Hyphoral include: upset stomach, stomach cramps, nausea and vomiting, diarrhoea or constipation, headache, rash, dizziness, tingling sensations, sensitivity to light, erectile dysfunction, swelling of the breast. What are the risks of using of Hyphoral? Ketoconazole in Hyphoral tablets 200mg can cause serious liver toxicity and can result in the need for liver transplant or be fatal. Liver function should therefore be checked before and during treatment with Hyphoral tablets 200mg. Symptoms of liver toxicity include: nausea, vomiting feel tired, stomach pain or tenderness, weight loss, or loss of appetite, dark urine or light coloured stools, yellowing of the skin or the whites of the eyes, fever or rash. Ketoconazole in Hyphoral tablets 200mg can also cause QT prolongation due to changes in the electrical activity of the heart, which can cause irregular heart beat and can be life threatening When should Hyphoral not be used? You should not use Hyphoral tablets 200mg if you: are allergic to ketoconazole or any ingredients in Hyphoral are pregnant or are breastfeeding have liver disease or are recovering from hepatitis as there is a risk of serious liver damage have adrenal insufficiency have had an abnormal heart rhythm tracing (ECG) or anyone in your family have or have had a heart problem called “congenital long QT syndrome drink alcohol, as this may make you feel sick or cause headache in combination with ketoconazole are taking medicines that interact with Hyphoral, including terfenadine, mizolastine or astemizole for allergy, halofantrine for treating malaria, cisapride for reflux, statins for cholesterol lowering (simvastatin, atrovastatin lovastatin) pimozide for mental disorders, calcium channel blockers (bepridil, epleronone, nisoldipine) for angina and high blood pressure, medicines containing ergot alkaloids such as ergotamine, antiarrhythmic drugs for irregular heat beats (quinidine, disopyramide and dofetilide), irinotecan for cancer chemotherapy What medications interact with Hyphoral? Several medications interact with Hyphoral tablets 200mg and should either not be taken while you are taking Hyphoral or only after discussion and instruction from your doctor: Drugs that cause muscle problems with Hyphoral: the cholesterol lowering statins simvastatin, atrovastatin and lovastatin. Drugs that prolong the QT interval with with Hyphoral: pimozide for mental disorders, cisapride for reflux, methadone, the antiarrhythmics disopyramide, dofetilide, dronedarone, and ranolazine, medicines containing ergot alkaloids such as ergotamine Drugs that affect Hyphoral: ritonavir for HIV, anticonvulsants like phenytoin and carbamazepine, anti-infectives like rifampicin, nevirapine, isoniazid and rifabutin Drugs that are affected by Hyphoral: triazolam, midazolam, or alprazolam, halofantrine for treating malaria, terfenadine, mizolastine or astemizole for allergy, calcium channel blockers (bepridil, epleronone, nisoldipine) for angina and high blood pressure, irinotecan for cancer chemotherapy How should Hyphoral be taken? You should take your Hyphoral tablets 200mg swallowed whole with a glass of water and with food once a day. You should continue to take your Hyphoral tablets 200mg for 5-10 days or up to several months, depending on what you are being treated for and your doctor’s recommendations. Always finish your course of tablets even if you feel better, if not, the infection may not clear up completely. Do not take medicines that neutralise stomach acid within 2 hours of taking Hyphoral 200mg tablets, as sufficient stomach acid is required for ketoconazole to be absorbed and do not drink any alcohol while taking Hyphoral tablets 200mg. How long should you take Hyphoral? You should continue to take your Hyphoral tablets 200mg for 5-10 days or up to several months, depending on what you are being treated for and your doctor’s recommendations. Missed dose of Hyphoral If you miss a dose of Hyphoral tablets 200mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose. How should Hyphoral be stored? You should store your Hyphoral tablets 200mg below 25°C in a cool dry place.
Carodyl 75mg (Carprofen 75mg) Carodyl general information What is Carodyl used for? Carodyl chewable tablets 75mg are a medication used for dogs to treat and manage the pain and inflammation that can be caused by osteoarthritis. Many dogs suffer from osteoarthritis, particularly as they age. Osteoarthritis is caused by wear and tear of the joints and can cause pain, swelling and stiffness, particularly in the legs, hips and backbone, which can restrict your dog’s activity and cause lameness. Carodyl 75 can help relieve symptoms of osteoarthritis and improve your dog’s mobility. Carodyl 75 is also used to reduce pain following orthopaedic and soft tissue surgery in dogs. Carodyl 75 is intended for use for dogs only and should not be given to cats or other pets. How does Carodyl work? Carodyl chewable tablets 75mg contain carprofen a non-steroidal anti-inflammatory drug (NSAID) belonging to the propionic acid class that has anti-inflammatory, analgesic (pain relief) and antipyretic (reduces fever) properties. NSAIDs inhibit the cyclooxygenase (COX) enzyme responsible for the production of chemicals called prostaglandins, which are mediators of a variety of cellular processes as well as inflammation. There are two COX enzymes, COX1 which is needed for normal cell functions and COX-2 which is involved in the inflammatory process. Carprofen in Carodyl 75 acts specifically on the inhibition of COX-2 resulting in anti-inflammatory activity which relieves the pain, swelling and stiffness in the joints caused by osteoarthritis. Carodyl tablets 75mg are available as meaty flavoured chewable tablets that are more palatable and easier for dogs to swallow. What does Carodyl contain? Carodyl chewable tablets 75mg contains the active ingredient carprofen a non-steroidal anti-inflammatory drug (NSAID) that is used to treat pain and inflammation due to osteoarthritis and surgery in dogs. Treating osteoarthritis with Carodyl Carodyl 75 contains carprofen a non-steroidal anti-inflammatory drug (NSAID) used to treat dogs to help manage the pain and inflammation caused by osteoarthritis. Many dogs suffer from osteoarthritis, particularly as they age. Osteoarthritis is caused by wear and tear of the joints causing pain, swelling and stiffness, particularly in the legs, hips and backbone, which can restrict your dog’s activity and cause lameness. Carprofen in Carodyl 75 specifically inhibits the COX-2 enzyme responsible for the production of chemicals called prostaglandins, which are mediators of inflammation. The anti-inflammatory activity of carprofen in Carodyl 75 relieves the pain, swelling and stiffness in the joints caused by osteoarthritis. What are the side effects of Carodyl? The most commonly reported side effects when taking Carodyl 75 include; vomiting, diarrhoea, loss of appetite, lethargy and behavioural changes. When should Carodyl not be used? You should not use Carodyl 75 if your dog: has a sensitivity reaction to carprofen or any other NSAID or any ingredients in Carodyl is younger than 6 months is pregnant or lactating has a heart condition, liver or kidney disease or bleeding disorders has been given other NSAID medication, corticosteroids, some heart drugs (ACE inhibitors), some drugs for seizure control How should Carodyl be given? You should give your dog Carodyl 75 chewable tablets by mouth and with food. The recommended dose is 2-4mg per kg body weight (2.2lb) per day given in two equally divided doses. The same dose may be reduced to once daily after 7 days, depending on your dog’s response and your veterinarian’s recommendation. You should see signs of improvement within a few days. You should continue to give Carodyl 75 to your dog for as long as recommended by your veterinarian, which may be long term, as Carodyl 75 will help relieve symptoms of osteoarthritis in your dog but will not cure your dog’s condition. Dosage: 7-10kg (15.4–22lb) 37.5mg in half tablet 14-18kg (30-39.6lb) 75mg in one tablet How long should you give Carodyl? You should continue to give Carodyl 75 to your dog for as long as recommended by your veterinarian, which may be long term, as. Carodyl 75 will help relieve symptoms of osteoarthritis in your dog but will not cure your dog’s condition. Missed dose of Carodyl If you miss a dose of Carodyl 75 give it as soon as you remember, unless it is time to give the next dose, then skip the missed dose. Do not give a double dose. How should Carodyl be stored? You should store your Carodyl 75 below 25°C in a cool dry place and protect from light.
Oruvail SR (Ketoprofen 200mg) Oruvail general information What is Oruvail used for? Oruvail SR capsules 200mg are used to help manage symptoms caused by various chronic inflammatory diseases. These include rheumatoid arthritis, osteoarthritis (wear and tear) and ankylosing spondylitis, (an autoimmune inflammatory disease that affects the joints in the spine and pelvis and can cause fusion of the spine) to reduce pain, inflammation, tenderness, stiffness and swelling in the affected joints. Oruvail SR capsules 200mg do not cure the underlying disease but can relieve symptoms of pain and inflammation and improve the functional use of affected joints. Oruvail SR capsules 200mg are also used for acute articular and periarticular disorders, such as bursitis (inflammation of the fluid filled sac in the joints), capsulitis (inflammation of tendons in joints), synovitis (inflammation of the membrane surrounding joints), tendonitis (inflammation of tendons), fibrositis (inflammation of connective tissues in muscles and joints), cervical spondylitis (wear and tear in the neck spinal disks); also for musculoskeletal disorders, such as sprains, strains, lower back pain (lumbago, sciatica) and for gout (uric acid crystals in the joints) to relieve chronic pain and inflammation. Oruvail SR capsules 200mg are also used for relief dysmenorrhoea (menstrual pain) and in the treatment of post-operative pain. How does Oruvail work? Oruvail SR capsules 200mg contain ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID) that has anti-inflammatory, analgesic (pain relieving) and anti-pyretic properties (reduces fever). Ketoprofen in Oruvail SR capsules 200mg blocks the production of specific chemicals called prostaglandins (PG) that mediate inflammation, particularly PGE2, and works by inhibiting the enzyme cyclooxygenase (COX) including cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2) that is induced during the inflammation process and is responsible for the synthesis of inflammatory prostaglandins. Inhibition of COX-2 helps relieve the symptoms of inflammation, including pain, swelling, and joint stiffness. Inhibition of COX-1 is responsible for the gastrointestinal side effects that are due to inhibition of protective prostaglandins in the gut and disruption of regulation of acid content. Oruvail SR capsules 200mg contain multiple microbeads which are formulated for sustained controlled release. This provides a constant concentration of ketoprofen over a period of time, for maximum effectiveness and minimum side effects. What does Oruvail contain? Oruvail SR capsules 200mg contains the active ingredient ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID) that is used to treat pain and inflammation of chronic inflammatory bone and joint diseases, and other conditions. They also contain erythrosine, ethylcellulose, gelatin, non-pareil beads (PI 1014), shellac, colloidal anhydrous silica, sodium lauryl sulfate, purified talc and titanium dioxide. The 200mg capsules also contain Opacode Blue (PI 12300). Treating arthritis with Oruvail Oruvail SR capsules 200mg contain ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve pain and inflammation in joints affected with arthritis. Osteoarthritis a degenerative disease (also known as wear and tear), and rheumatoid arthritis (an autoimmune disease where the immune system turns on self) are chronic inflammatory diseases in which the joints become inflamed, swollen and painful. Ketoprofen in Oruvail SR capsules 200mg blocks the production of specific chemicals called prostaglandins (PG) that mediate inflammation, particularly PGE2, and works by inhibiting the enzyme cyclooxygenase (COX) that is responsible for the synthesis of inflammatory prostaglandins. Inhibition of PG production by ketoprofen in Oruvail SR capsules 200mg helps relieve the symptoms of inflammation, including pain, swelling, and joint stiffness, to improve the functional use of affected joints., but does not cure the underlying disease. Oruvail for pain and inflammation Oruvail SR capsules 200mg contain ketoprofen a nonsteroidal anti-inflammatory drug (NSAID) that is used to treat several chronic inflammatory joint diseases to relieve pain and inflammation. These include rheumatoid arthritis, osteoarthritis (wear and tear), ankylosing spondylitis (an autoimmune inflammatory disease that affects the joints in the spine and pelvis and can cause fusion of the spine). Oruvail SR capsules 200mg are also used for musculoskeletal disorders, such as sprains, strains, lower back pain (lumbago) to relieve chronic pain and inflammation; also to treat rheumatic conditions of the connective tissue surrounding joints (non-articular), including bursitis, tendonitis, synovitis and fibrositis. Oruvail SR capsules 200mg are also used for acute pain and inflammation are also associated with dysmenorrhea (menstrual pain) and post-operative pain (following surgery). Ketoprofen in Oruvail SR capsules 200mg blocks the production of specific chemicals called prostaglandins (PG) that mediate inflammation, particularly PGE2, and works by inhibiting the enzyme cyclooxygenase (COX) including cyclooxygenase 2 (COX-2) that is induced during the inflammation process and is responsible for the synthesis of inflammatory prostaglandins. Inhibition of COX-2 helps relieve the symptoms of inflammation, including pain, swelling, and joint stiffness. Oruvail SR capsules 200mg also inhibit cyclooxygenase 1 (COX-1), which is thought to be responsible for the gastrointestinal side effects associated with the non-selective NSAIDs. What are the side effects of Oruvail? The most commonly reported side effects when taking Oruvail SR capsules 200mg are gastrointestinal and include: upset stomach or stomach pain, diarrhoea, indigestion, bloating wind, heartburn, indigestion, constipation. Other side effects include dizziness, headache, visual disturbance, tinnitus (buzzing or ringing in the ears), skin rash, oedema and fluid retention. When should Oruvail not be used? You should not use Oruvail SR capsules 200mg if you: are allergic to ketoprofen or any other NSAID including aspirin or any ingredients in Oruvail are pregnant or are breastfeeding, without discussion with your have kidney or liver disease have asthma as ketoprofen may cause bronchospasm have uncontrolled hypertension, severe heart failure or cardiovascular disease, without discussion with your doctor have active or a history of gastrointestinal bleeding or perforation due to an ulcer have a tendency to bleed easily are taking medicines that interact with Oruvail, aspirin or other NSAIDs, anticoagulants like warfarin, cholestyramine for high cholesterol, probenecid for gout, the anti-cancer drug methotrexate, lithium for mood disorders, diuretics like frusemide, beta blockers and ACE inhibitors for high blood pressure, digitalis for heart failure, sulphonamide antibiotics, sulphonylureas for diabetes, SSRI antidepressants, corticosteroids What medications interact with Oruvail? Several medications interact with Oruvail SR capsules 200mg and should either not be taken while you are taking Oruvail or only after discussion and instruction from your doctor: Drugs that cause a serious reaction with Oruvail: aspirin or other NSAIDs, SSRI antidepressants, anticoagulants like warfarin, and ACE inhibitors Drugs that affect Oruvail: cholestyramine for high cholesterol, probenecid for gout Drugs that are affected by Oruvail: anticoagulants like warfarin, the anti-cancer drug methotrexate, lithium for mood disorders, diuretics like frusemide, beta blockers and ACE inhibitors for high blood pressure, sulphonamide antibiotics, sulphonylureas for diabetes How should Oruvail be taken? You should take your Oruvail SR capsules 200mg swallowed whole with a glass of water once daily at the same time each day and with food to reduce risk of gastrointestinal side effects. The dose you take depends on your condition and your doctor’s recommendation. You should continue to take your Oruvail SR capsules 200mg for as long as recommended by your doctor, which may be for a few days, several weeks or longer, depending on what you are being treated for. How long should you take Oruvail? You should continue to take your Oruvail SR capsules 200mg for as long as recommended by your doctor, which may be for a few days, several weeks or longer, depending on what you are being treated for. Missed dose of Oruvail If you miss a dose of Oruvail SR capsules 200mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose. How should Oruvail be stored? You should store your Oruvail SR capsules 200mg below 25°C in a cool dry place.
Wysolone 5 (Prednisolone 5mg) Wysolone general information What is Wysolone used for? Wysolone tablets 5mg are a steroid medication used in wide range of inflammatory, allergic and immune disorders to suppress clinical symptoms of the disease. Amongst their many applications, Wysolone tablets 5mg are used to reduce inflammation in conditions where the immune system is overactive, like anaphylaxis, severe asthma, acute outbreaks of eczema and severe allergies; to reduce inflammation and suppress the immune system in autoimmune diseases like rheumatoid arthritis, systemic lupus erythematosus, ulcerative colitis or Crohn's disease, where the body’s immune system is directed against self, and to prevent rejection following organ transplant. Wysolone 5 is also used as an anti-cancer medication along with other drugs, to treat certain tumours like leukemia and lymphoma, and to replace a lack natural corticosteroid cortisol in conditions where there is not enough produced, such as underactive adrenal glands or congenital adrenal hyperplasia, which can affect the ability of the body to regulate blood pressure, blood sugar, energy levels, normal development and protect against stress. How does Wysolone work? Wysolone tablets 5mg contain prednisolone, which is corticosteroid hormone and is a synthetic derivative of the natural glucocorticoid cortisol. Prednisolone is the active metabolite of prednisone and can be converted from prednisone into prednisolone in the liver. Prednisolone in Wysolone 5 acts directly through the glucocorticoid receptor that is expressed inside most cells of the body and regulates transcription of specific genes that control many aspects of development, metabolism and the immune response. Prednisolone in Wysolone 5 has potent anti-inflammatory, anti-allergic, anti-rheumatic and immunosuppressant properties and has widespread effects acting on most tissues in the body to modify, glucose, fat, protein and calcium metabolism. The major therapeutic actions of prednisolone are to reduce the vascular (blood vessels) and cellular inflammatory response primarily by blocking the production of inflammatory chemicals, like prostaglandins and leukotrienes, from inflammatory cells to reduce the swelling, redness and pain associated with inflammation; to modify the actions of cells involved in the allergic response, and to suppress the immune system to prevent rejection following organ transplant. Prednisolone in Wysolone 5 also has anti-cancer properties and is used to prevent growth of certain tumours like leukemia and lymphoma. What does Wysolone contain? Wysolone tablets 5mg contain the active ingredient prednisolone a potent synthetic corticosteroid used to treat a wide range of inflammatory, allergic and immune disorders. What is the difference between prednisone and prednisolone? Prednisone is an inactive drug precursor that must be converted to prednisolone in the liver to become active. Prednisolone is particularly helpful for patients with liver problems who cannot metabolise prednisone into prednisolone in the liver. Treating inflammation with Wysolone Wysolone tablets 5mg contain prednisolone, which is a corticosteroid hormone and is a synthetic derivative of the natural glucocorticoid cortisol, with potent anti-inflammatory, anti-allergic, anti-rheumatic and immunosuppressant properties. Wysolone 5 is used in a wide range of inflammatory disorders, to suppress clinical symptoms of the disease where inflammation is caused by many different factors. For example, where the immune system is overactive, like severe asthma, acute outbreaks of eczema and severe allergies; autoimmune diseases, where the immune system is directed against self, like rheumatoid arthritis, systemic lupus erythematosus or Crohn's disease. The anti-inflammatory actions of prednisolone in Wysolone tablets 5mg are to block the production of inflammatory chemicals, like prostaglandins and leukotrienes, from inflammatory cells which reduces the swelling, redness and pain associated with inflammation. What are the side effects of Wysolone? The most commonly reported side effects when taking Wysolone 5 include: increased susceptibility to infection, muscle or bone aches and pains, weight gain, thinning of skin, bone demineralisation, slow wound healing, acne, redistribution of body fat creating the typical moon face, altered vision. Also behavioural and mood disturbances such as depression, irritability, anxiety, sleep disturbances. What are the health risks of taking Wysolone? Long term use of Wysolone 5 may cause the adrenal glands, which produce endogenous (naturally occurring) corticosteroids, to stop working efficiently. This may slow down the growth rate in children and will need regular monitoring. Wysolone 5 may also cause decreased bone mineral density, if used for long periods. Long term use of steroids may be associated with a range of side effects such as round face, altered body shape, altered hair growth, thinning of the bones, decreased resistance to infection, increased salt and water retention, increased blood pressure and diabetes. When should Wysolone not be used? You should not use Wysolone 5 if you: are allergic to prednisolone or any ingredients in Wysolone are pregnant or are breastfeeding have thyroid, stomach, heart, kidney or liver problems, high blood pressure, mood disorders, epilepsy, diabetes, glaucoma, osteoporosis have any infectious disease, acute infection, systemic fungal infection, tuberculosis, uncomplicated viral hepatitis are due to receive a vaccination with a live virus vaccine are taking medicines that interact with Wysolone like anti-inflammatories such as; diclofenac, ibuprofen, mefenamic acidor naproxen; barbiturates, phenylbutazone, phenytoin or rifampicin, anticoagulants, insulin for diabetes are taking diuretic medicines such as the thiazides or frusemide, these may cause increased loss of potassium when taken with Wysolone 5 What medications interact with Wysolone? Several medications interact with Wysolone and should either not be taken while you are taking Wysolone or only after discussion and instruction from your doctor: Drugs that cause a serious reaction with Wysolone: anti-inflammatories such as; diclofenac, ibuprofen, mefenamic acidor naproxen Drugs that affect Wysolone: rifampicin, barbiturates, phenylbutazone, phenytoin Drugs that are affected by Wysolone: live virus vaccine may be less effective, anticoagulants, insulin for diabetes How should Wysolone be taken? You should take your Wysolone tablets 5mg swallowed whole with a glass of water and with food. The dose of Wysolone 5 that you take, how often and for how long depends on what you are being treated for and as recommended by your doctor. You should continue to take your Wysolone 5 for as long as recommended by your doctor and should not stop taking them suddenly; withdrawal should be gradual to reduce risk of side effects. How long should you take Wysolone? You should continue to take your Wysolone 5 for as long as recommended by your doctor and should not stop taking them suddenly; withdrawal should be gradual to reduce risk of side effects. Missed dose of Wysolone If you miss a dose of Wysolone 5 take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose. How should Wysolone be stored? You should store your Wysolone below 25°C in a cool dry place.

Are you looking for:

Kenozole general information

What is Kenozole used for?

Kenozole Cream 2% is used as a topical treatment for fungal infections of the skin and scalp, due to the Tinea fungus. Tinea is a dermatophyte fungus also known as ringworm. Tinea causes fungal infection in different parts of the body including ringworm of the foot, also known as Athlete's foot (tinea pedis), of the body (tinea corporis), of the groin (tinea cruris or jock itch), and of the scalp (tinea capitis). Kenozole Cream 2% is also used to treat infection by the yeast fungus Malassezia, which causes Pityriasis versicolor, characterised by flaky discoloured patches that appear on the chest and back and seborrhoeic dermatitis, a form of dermatitis or inflammation of the skin that affects mainly the scalp and face. Kenozole Cream 2% is also effective against infection with the yeast fungus Candida, which causes cutaneous candidiasis, characterised by itchy red rash on various parts of the body, usually in warm, moist creased areas of skin, like under the arms and in the groin.

How does Kenozole work?

Kenozole Cream 2% contains ketoconazole, a synthetic broad-spectrum antifungal that is used to treat a variety of fungal infections of the skin. Ketoconazole in Kenozole Cream 2% prevents growth of dermatophyte and yeast fungi by inhibiting the synthesis of ergosterol, an important component of fungal cell membrane that is not found in animal cells. This results in altering the permeability of the fungal cell membrane causing it to become weakened, so that the cell contents to leak out, which kills the fungus, preventing the infection from spreading and relieving symptoms caused by the fungal infection, including pain and inflammation. When used as a topical antifungal, no detectable ketoconazole enters the blood, reducing risk of systemic side effects.

What does Kenozole contain?

Kenozole Cream contains the active ingredient ketoconazole 2% (w/w), a synthetic broad-spectrum antifungal that is used to treat a variety of fungal infections.

Treating fungal infections with Kenozole

Kenozole Cream 2% contains ketoconazole, a synthetic broad-spectrum antifungal that is used to treat a variety of fungal infections due to dermatophyte fungus Tinea, known as ringworm and the yeast Candida. These infections include, ringworm of the foot, also known as Athlete's foot (tinea pedis), of the body (tinea corporis), of the groin (tinea cruris or jock itch), and of the scalp (tinea capitis). Malassezia is a yeast-like fungus that causes Pityriasis versicolor, characterised by flaky discoloured patches that appear on the chest and back and seborrhoeic dermatitis, a form of dermatitis or inflammation of the skin that affects mainly the scalp and face. Candida causes cutaneous candidiasis, characterised by itchy red rash on various parts of the body, usually in warm, moist creased areas of skin, like under the arms and in the groin. Ketoconazole in Kenozole Cream 2% prevents growth of dermatophyte and yeast fungi by inhibiting the synthesis of ergosterol, an important component of fungal cell membrane that is not found in animal cells. This results in altering the permeability of the fungal cell membrane causing it to become weakened, so that the cell contents to leak out, which kills the fungus, preventing the infection from spreading and relieving symptoms caused by the fungal infection, including pain and inflammation.

What are the side effects of Kenozole?

The most commonly reported side effects when using Kenozole Cream 2% include, burning sensation or irritation at the site of application, such as redness, pain and swelling; oily or dry scalp, mild hair loss.

When should Kenozole not be used?

You should not use Kenozole Cream 2% if you:

are allergic to ketoconazole or any ingredients in Kenozole
are pregnant or are breastfeeding, without discussion with your doctor

How should Kenozole be used?

You should apply your Kenozole Cream 2% to the affected area and rub gently into the skin once or twice daily depending on what you are being treated for and the severity of the infection. You should continue your course of treatment with Kenozole Cream for 2-6 weeks, depending on what you are being treated for and your doctor’s recommendation, until signs and symptoms of the infection has disappeared. Wash your hands to prevent spreading the infection and do not get the cream into your eyes.

How long should you take Kenozole?

You should continue your course of treatment with Kenozole Cream for 2-6 weeks, depending on what you are being treated for and your doctor’s recommendation.

Missed dose of Kenozole

If you miss a dose of Kenozole apply it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.

How should Kenozole be stored?

You should store your Kenozole below 25°C in a cool dry place.

Hyphoral 200mg (Ketoconazole)

Hyphoral general information

What is Hyphoral used for?

Hyphoral tablets 200mg are used to treat severe systemic fungal infections only in patients who cannot tolerate other treatments or where other treatments have failed and where the potential benefits are considered to outweigh the potential risks. Hyphoral tablets 200mg are used for systemic fungal infections caused by inhalation of the spores of a soil fungus that can affect internal organs and cause influenza-like illness with fever, cough, headaches, skin rash, and myalgia (muscle pain), such as coccidioidomycosis caused by Coccidioides immitis, Blastomycosis, caused by Blastomyces dermatitidis and histoplasmosis caused by Histoplasma capsulatum. Serious symptoms can develop including chronic lung infection and widespread infection reaching the bones, skin and urinogenital tract. Hyphoral 200 is also used to treat chromomycosis, caused by penetration of the skin by a thorn or splinter and infection by several different fungal species that spread slowly through the skin. Hyphoral tablets 200mg should not be used to treat fungal meningitis as the medication cannot penetrate into the nervous system.

How does Hyphoral work?

Hyphoral tablets 200mg contain ketoconazole, a synthetic broad-spectrum antifungal agent that specifically kills the fungus by inhibiting the synthesis of ergosterol, an important component of fungal cell membrane that is not found in animal cells. Ketoconazole in Hyphoral tablets 200mg weakens the fungal cell membrane, causing the cell contents to leak out which kills the fungus, preventing the infection from spreading and relieving symptoms caused by the fungal infection, including pain and inflammation.

What does Hyphoral contain?

Hyphoral tablets 200mg contain the active ingredient ketoconazole, a synthetic broad-spectrum antifungal used to treat severe systemic fungal infections.

Treating systemic fungal infection with Hyphoral

Hyphoral tablets 200mg contain ketoconazole, a synthetic broad-spectrum antifungal agent that is used to treat severe systemic fungal infections in patients who cannot tolerate other treatments or where other treatments have failed and where the potential benefits are considered to outweigh the potential risks. These infections include coccidioidomycosis, histoplasmosis and blastomycosis, which are all caused by inhalation of spores produced by soil fungi. Symptoms usually include influenza-like illness with fever, cough, headaches, skin rash, and myalgia (muscle pain), however, these infections can be difficult to treat and can affect internal organs causing serious symptoms including chronic lung infection and widespread infection reaching the bones, skin and urinogenital tract. Ketoconazole in Hyphoral tablets 200mg inhibits the synthesis of ergosterol, an important component of fungal cell membrane that is not found in animal cells, which weakens the fungal cell membrane, causing the cell contents to leak out which kills the fungus, preventing the infection from spreading.

What are the side effects of Hyphoral?

The most commonly reported side effects when taking Hyphoral include: upset stomach, stomach cramps, nausea and vomiting, diarrhoea or constipation, headache, rash, dizziness, tingling sensations, sensitivity to light, erectile dysfunction, swelling of the breast.

What are the risks of using of Hyphoral?

Ketoconazole in Hyphoral tablets 200mg can cause serious liver toxicity and can result in the need for liver transplant or be fatal. Liver function should therefore be checked before and during treatment with Hyphoral tablets 200mg. Symptoms of liver toxicity include: nausea, vomiting feel tired, stomach pain or tenderness, weight loss, or loss of appetite, dark urine or light coloured stools, yellowing of the skin or the whites of the eyes, fever or rash. Ketoconazole in Hyphoral tablets 200mg can also cause QT prolongation due to changes in the electrical activity of the heart, which can cause irregular heart beat and can be life threatening

When should Hyphoral not be used?

You should not use Hyphoral tablets 200mg if you:

are allergic to ketoconazole or any ingredients in Hyphoral
are pregnant or are breastfeeding
have liver disease or are recovering from hepatitis as there is a risk of serious liver damage
have adrenal insufficiency
have had an abnormal heart rhythm tracing (ECG) or anyone in your family have or have had a heart problem called “congenital long QT syndrome
drink alcohol, as this may make you feel sick or cause headache in combination with ketoconazole
are taking medicines that interact with Hyphoral, including terfenadine, mizolastine or astemizole for allergy, halofantrine for treating malaria, cisapride for reflux, statins for cholesterol lowering (simvastatin, atrovastatin lovastatin) pimozide for mental disorders, calcium channel blockers (bepridil, epleronone, nisoldipine) for angina and high blood pressure, medicines containing ergot alkaloids such as ergotamine, antiarrhythmic drugs for irregular heat beats (quinidine, disopyramide and dofetilide), irinotecan for cancer chemotherapy

What medications interact with Hyphoral?

Several medications interact with Hyphoral tablets 200mg and should either not be taken while you are taking Hyphoral or only after discussion and instruction from your doctor:

Drugs that cause muscle problems with Hyphoral: the cholesterol lowering statins simvastatin, atrovastatin and lovastatin.
Drugs that prolong the QT interval with with Hyphoral: pimozide for mental disorders, cisapride for reflux, methadone, the antiarrhythmics disopyramide, dofetilide, dronedarone, and ranolazine, medicines containing ergot alkaloids such as ergotamine
Drugs that affect Hyphoral: ritonavir for HIV, anticonvulsants like phenytoin and carbamazepine, anti-infectives like rifampicin, nevirapine, isoniazid and rifabutin
Drugs that are affected by Hyphoral: triazolam, midazolam, or alprazolam, halofantrine for treating malaria, terfenadine, mizolastine or astemizole for allergy, calcium channel blockers (bepridil, epleronone, nisoldipine) for angina and high blood pressure, irinotecan for cancer chemotherapy

How should Hyphoral be taken?

You should take your Hyphoral tablets 200mg swallowed whole with a glass of water and with food once a day. You should continue to take your Hyphoral tablets 200mg for 5-10 days or up to several months, depending on what you are being treated for and your doctor’s recommendations. Always finish your course of tablets even if you feel better, if not, the infection may not clear up completely. Do not take medicines that neutralise stomach acid within 2 hours of taking Hyphoral 200mg tablets, as sufficient stomach acid is required for ketoconazole to be absorbed and do not drink any alcohol while taking Hyphoral tablets 200mg.

How long should you take Hyphoral?

You should continue to take your Hyphoral tablets 200mg for 5-10 days or up to several months, depending on what you are being treated for and your doctor’s recommendations.

Missed dose of Hyphoral

If you miss a dose of Hyphoral tablets 200mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.

How should Hyphoral be stored?

You should store your Hyphoral tablets 200mg below 25°C in a cool dry place.

Carodyl 75mg (Carprofen 75mg)

Carodyl general information

What is Carodyl used for?

Carodyl chewable tablets 75mg are a medication used for dogs to treat and manage the pain and inflammation that can be caused by osteoarthritis. Many dogs suffer from osteoarthritis, particularly as they age. Osteoarthritis is caused by wear and tear of the joints and can cause pain, swelling and stiffness, particularly in the legs, hips and backbone, which can restrict your dog’s activity and cause lameness. Carodyl 75 can help relieve symptoms of osteoarthritis and improve your dog’s mobility. Carodyl 75 is also used to reduce pain following orthopaedic and soft tissue surgery in dogs. Carodyl 75 is intended for use for dogs only and should not be given to cats or other pets.

How does Carodyl work?

Carodyl chewable tablets 75mg contain carprofen a non-steroidal anti-inflammatory drug (NSAID) belonging to the propionic acid class that has anti-inflammatory, analgesic (pain relief) and antipyretic (reduces fever) properties. NSAIDs inhibit the cyclooxygenase (COX) enzyme responsible for the production of chemicals called prostaglandins, which are mediators of a variety of cellular processes as well as inflammation. There are two COX enzymes, COX1 which is needed for normal cell functions and COX-2 which is involved in the inflammatory process. Carprofen in Carodyl 75 acts specifically on the inhibition of COX-2 resulting in anti-inflammatory activity which relieves the pain, swelling and stiffness in the joints caused by osteoarthritis. Carodyl tablets 75mg are available as meaty flavoured chewable tablets that are more palatable and easier for dogs to swallow.

What does Carodyl contain?

Carodyl chewable tablets 75mg contains the active ingredient carprofen a non-steroidal anti-inflammatory drug (NSAID) that is used to treat pain and inflammation due to osteoarthritis and surgery in dogs.

Treating osteoarthritis with Carodyl

Carodyl 75 contains carprofen a non-steroidal anti-inflammatory drug (NSAID) used to treat dogs to help manage the pain and inflammation caused by osteoarthritis. Many dogs suffer from osteoarthritis, particularly as they age. Osteoarthritis is caused by wear and tear of the joints causing pain, swelling and stiffness, particularly in the legs, hips and backbone, which can restrict your dog’s activity and cause lameness. Carprofen in Carodyl 75 specifically inhibits the COX-2 enzyme responsible for the production of chemicals called prostaglandins, which are mediators of inflammation. The anti-inflammatory activity of carprofen in Carodyl 75 relieves the pain, swelling and stiffness in the joints caused by osteoarthritis.

What are the side effects of Carodyl?

The most commonly reported side effects when taking Carodyl 75 include; vomiting, diarrhoea, loss of appetite, lethargy and behavioural changes.

When should Carodyl not be used?

You should not use Carodyl 75 if your dog:

has a sensitivity reaction to carprofen or any other NSAID or any ingredients in Carodyl
is younger than 6 months
is pregnant or lactating
has a heart condition, liver or kidney disease or bleeding disorders
has been given other NSAID medication, corticosteroids, some heart drugs (ACE inhibitors), some drugs for seizure control

How should Carodyl be given?

You should give your dog Carodyl 75 chewable tablets by mouth and with food. The recommended dose is 2-4mg per kg body weight (2.2lb) per day given in two equally divided doses. The same dose may be reduced to once daily after 7 days, depending on your dog’s response and your veterinarian’s recommendation. You should see signs of improvement within a few days. You should continue to give Carodyl 75 to your dog for as long as recommended by your veterinarian, which may be long term, as Carodyl 75 will help relieve symptoms of osteoarthritis in your dog but will not cure your dog’s condition.

Dosage:

7-10kg (15.4–22lb) 37.5mg in half tablet

14-18kg (30-39.6lb) 75mg in one tablet

How long should you give Carodyl?

You should continue to give Carodyl 75 to your dog for as long as recommended by your veterinarian, which may be long term, as. Carodyl 75 will help relieve symptoms of osteoarthritis in your dog but will not cure your dog’s condition.

Missed dose of Carodyl

If you miss a dose of Carodyl 75 give it as soon as you remember, unless it is time to give the next dose, then skip the missed dose. Do not give a double dose.

How should Carodyl be stored?

You should store your Carodyl 75 below 25°C in a cool dry place and protect from light.

Oruvail SR (Ketoprofen 200mg)

Oruvail general information

What is Oruvail used for?

Oruvail SR capsules 200mg are used to help manage symptoms caused by various chronic inflammatory diseases. These include rheumatoid arthritis, osteoarthritis (wear and tear) and ankylosing spondylitis, (an autoimmune inflammatory disease that affects the joints in the spine and pelvis and can cause fusion of the spine) to reduce pain, inflammation, tenderness, stiffness and swelling in the affected joints. Oruvail SR capsules 200mg do not cure the underlying disease but can relieve symptoms of pain and inflammation and improve the functional use of affected joints. Oruvail SR capsules 200mg are also used for acute articular and periarticular disorders, such as bursitis (inflammation of the fluid filled sac in the joints), capsulitis (inflammation of tendons in joints), synovitis (inflammation of the membrane surrounding joints), tendonitis (inflammation of tendons), fibrositis (inflammation of connective tissues in muscles and joints), cervical spondylitis (wear and tear in the neck spinal disks); also for musculoskeletal disorders, such as sprains, strains, lower back pain (lumbago, sciatica) and for gout (uric acid crystals in the joints) to relieve chronic pain and inflammation. Oruvail SR capsules 200mg are also used for relief dysmenorrhoea (menstrual pain) and in the treatment of post-operative pain.

How does Oruvail work?

Oruvail SR capsules 200mg contain ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID) that has anti-inflammatory, analgesic (pain relieving) and anti-pyretic properties (reduces fever). Ketoprofen in Oruvail SR capsules 200mg blocks the production of specific chemicals called prostaglandins (PG) that mediate inflammation, particularly PGE2, and works by inhibiting the enzyme cyclooxygenase (COX) including cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2) that is induced during the inflammation process and is responsible for the synthesis of inflammatory prostaglandins. Inhibition of COX-2 helps relieve the symptoms of inflammation, including pain, swelling, and joint stiffness. Inhibition of COX-1 is responsible for the gastrointestinal side effects that are due to inhibition of protective prostaglandins in the gut and disruption of regulation of acid content. Oruvail SR capsules 200mg contain multiple microbeads which are formulated for sustained controlled release. This provides a constant concentration of ketoprofen over a period of time, for maximum effectiveness and minimum side effects.

What does Oruvail contain?

Oruvail SR capsules 200mg contains the active ingredient ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID) that is used to treat pain and inflammation of chronic inflammatory bone and joint diseases, and other conditions. They also contain erythrosine, ethylcellulose, gelatin, non-pareil beads (PI 1014), shellac, colloidal anhydrous silica, sodium lauryl sulfate, purified talc and titanium dioxide. The 200mg capsules also contain Opacode Blue (PI 12300).

Treating arthritis with Oruvail

Oruvail SR capsules 200mg contain ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve pain and inflammation in joints affected with arthritis. Osteoarthritis a degenerative disease (also known as wear and tear), and rheumatoid arthritis (an autoimmune disease where the immune system turns on self) are chronic inflammatory diseases in which the joints become inflamed, swollen and painful. Ketoprofen in Oruvail SR capsules 200mg blocks the production of specific chemicals called prostaglandins (PG) that mediate inflammation, particularly PGE2, and works by inhibiting the enzyme cyclooxygenase (COX) that is responsible for the synthesis of inflammatory prostaglandins. Inhibition of PG production by ketoprofen in Oruvail SR capsules 200mg helps relieve the symptoms of inflammation, including pain, swelling, and joint stiffness, to improve the functional use of affected joints., but does not cure the underlying disease.

Oruvail for pain and inflammation

Oruvail SR capsules 200mg contain ketoprofen a nonsteroidal anti-inflammatory drug (NSAID) that is used to treat several chronic inflammatory joint diseases to relieve pain and inflammation. These include rheumatoid arthritis, osteoarthritis (wear and tear), ankylosing spondylitis (an autoimmune inflammatory disease that affects the joints in the spine and pelvis and can cause fusion of the spine). Oruvail SR capsules 200mg are also used for musculoskeletal disorders, such as sprains, strains, lower back pain (lumbago) to relieve chronic pain and inflammation; also to treat rheumatic conditions of the connective tissue surrounding joints (non-articular), including bursitis, tendonitis, synovitis and fibrositis. Oruvail SR capsules 200mg are also used for acute pain and inflammation are also associated with dysmenorrhea (menstrual pain) and post-operative pain (following surgery). Ketoprofen in Oruvail SR capsules 200mg blocks the production of specific chemicals called prostaglandins (PG) that mediate inflammation, particularly PGE2, and works by inhibiting the enzyme cyclooxygenase (COX) including cyclooxygenase 2 (COX-2) that is induced during the inflammation process and is responsible for the synthesis of inflammatory prostaglandins. Inhibition of COX-2 helps relieve the symptoms of inflammation, including pain, swelling, and joint stiffness. Oruvail SR capsules 200mg also inhibit cyclooxygenase 1 (COX-1), which is thought to be responsible for the gastrointestinal side effects associated with the non-selective NSAIDs.

What are the side effects of Oruvail?

The most commonly reported side effects when taking Oruvail SR capsules 200mg are gastrointestinal and include: upset stomach or stomach pain, diarrhoea, indigestion, bloating wind, heartburn, indigestion, constipation. Other side effects include dizziness, headache, visual disturbance, tinnitus (buzzing or ringing in the ears), skin rash, oedema and fluid retention.

When should Oruvail not be used?

You should not use Oruvail SR capsules 200mg if you:

are allergic to ketoprofen or any other NSAID including aspirin or any ingredients in Oruvail
are pregnant or are breastfeeding, without discussion with your
have kidney or liver disease
have asthma as ketoprofen may cause bronchospasm
have uncontrolled hypertension, severe heart failure or cardiovascular disease, without discussion with your doctor
have active or a history of gastrointestinal bleeding or perforation due to an ulcer
have a tendency to bleed easily
are taking medicines that interact with Oruvail, aspirin or other NSAIDs, anticoagulants like warfarin, cholestyramine for high cholesterol, probenecid for gout, the anti-cancer drug methotrexate, lithium for mood disorders, diuretics like frusemide, beta blockers and ACE inhibitors for high blood pressure, digitalis for heart failure, sulphonamide antibiotics, sulphonylureas for diabetes, SSRI antidepressants, corticosteroids

What medications interact with Oruvail?

Several medications interact with Oruvail SR capsules 200mg and should either not be taken while you are taking Oruvail or only after discussion and instruction from your doctor:

Drugs that cause a serious reaction with Oruvail: aspirin or other NSAIDs, SSRI antidepressants, anticoagulants like warfarin, and ACE inhibitors
Drugs that affect Oruvail: cholestyramine for high cholesterol, probenecid for gout
Drugs that are affected by Oruvail: anticoagulants like warfarin, the anti-cancer drug methotrexate, lithium for mood disorders, diuretics like frusemide, beta blockers and ACE inhibitors for high blood pressure, sulphonamide antibiotics, sulphonylureas for diabetes

How should Oruvail be taken?

You should take your Oruvail SR capsules 200mg swallowed whole with a glass of water once daily at the same time each day and with food to reduce risk of gastrointestinal side effects. The dose you take depends on your condition and your doctor’s recommendation. You should continue to take your Oruvail SR capsules 200mg for as long as recommended by your doctor, which may be for a few days, several weeks or longer, depending on what you are being treated for.

How long should you take Oruvail?

You should continue to take your Oruvail SR capsules 200mg for as long as recommended by your doctor, which may be for a few days, several weeks or longer, depending on what you are being treated for.

Missed dose of Oruvail

If you miss a dose of Oruvail SR capsules 200mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.

How should Oruvail be stored?

You should store your Oruvail SR capsules 200mg below 25°C in a cool dry place.

Wysolone 5 (Prednisolone 5mg)

Wysolone general information

What is Wysolone used for?

Wysolone tablets 5mg are a steroid medication used in wide range of inflammatory, allergic and immune disorders to suppress clinical symptoms of the disease. Amongst their many applications, Wysolone tablets 5mg are used to reduce inflammation in conditions where the immune system is overactive, like anaphylaxis, severe asthma, acute outbreaks of eczema and severe allergies; to reduce inflammation and suppress the immune system in autoimmune diseases like rheumatoid arthritis, systemic lupus erythematosus, ulcerative colitis or Crohn's disease, where the body’s immune system is directed against self, and to prevent rejection following organ transplant. Wysolone 5 is also used as an anti-cancer medication along with other drugs, to treat certain tumours like leukemia and lymphoma, and to replace a lack natural corticosteroid cortisol in conditions where there is not enough produced, such as underactive adrenal glands or congenital adrenal hyperplasia, which can affect the ability of the body to regulate blood pressure, blood sugar, energy levels, normal development and protect against stress.

How does Wysolone work?

Wysolone tablets 5mg contain prednisolone, which is corticosteroid hormone and is a synthetic derivative of the natural glucocorticoid cortisol. Prednisolone is the active metabolite of prednisone and can be converted from prednisone into prednisolone in the liver. Prednisolone in Wysolone 5 acts directly through the glucocorticoid receptor that is expressed inside most cells of the body and regulates transcription of specific genes that control many aspects of development, metabolism and the immune response. Prednisolone in Wysolone 5 has potent anti-inflammatory, anti-allergic, anti-rheumatic and immunosuppressant properties and has widespread effects acting on most tissues in the body to modify, glucose, fat, protein and calcium metabolism. The major therapeutic actions of prednisolone are to reduce the vascular (blood vessels) and cellular inflammatory response primarily by blocking the production of inflammatory chemicals, like prostaglandins and leukotrienes, from inflammatory cells to reduce the swelling, redness and pain associated with inflammation; to modify the actions of cells involved in the allergic response, and to suppress the immune system to prevent rejection following organ transplant. Prednisolone in Wysolone 5 also has anti-cancer properties and is used to prevent growth of certain tumours like leukemia and lymphoma.

What does Wysolone contain?

Wysolone tablets 5mg contain the active ingredient prednisolone a potent synthetic corticosteroid used to treat a wide range of inflammatory, allergic and immune disorders.

What is the difference between prednisone and prednisolone?

Prednisone is an inactive drug precursor that must be converted to prednisolone in the liver to become active. Prednisolone is particularly helpful for patients with liver problems who cannot metabolise prednisone into prednisolone in the liver.

Treating inflammation with Wysolone

Wysolone tablets 5mg contain prednisolone, which is a corticosteroid hormone and is a synthetic derivative of the natural glucocorticoid cortisol, with potent anti-inflammatory, anti-allergic, anti-rheumatic and immunosuppressant properties. Wysolone 5 is used in a wide range of inflammatory disorders, to suppress clinical symptoms of the disease where inflammation is caused by many different factors. For example, where the immune system is overactive, like severe asthma, acute outbreaks of eczema and severe allergies; autoimmune diseases, where the immune system is directed against self, like rheumatoid arthritis, systemic lupus erythematosus or Crohn's disease. The anti-inflammatory actions of prednisolone in Wysolone tablets 5mg are to block the production of inflammatory chemicals, like prostaglandins and leukotrienes, from inflammatory cells which reduces the swelling, redness and pain associated with inflammation.

What are the side effects of Wysolone?

The most commonly reported side effects when taking Wysolone 5 include: increased susceptibility to infection, muscle or bone aches and pains, weight gain, thinning of skin, bone demineralisation, slow wound healing, acne, redistribution of body fat creating the typical moon face, altered vision. Also behavioural and mood disturbances such as depression, irritability, anxiety, sleep disturbances.

What are the health risks of taking Wysolone?

Long term use of Wysolone 5 may cause the adrenal glands, which produce endogenous (naturally occurring) corticosteroids, to stop working efficiently. This may slow down the growth rate in children and will need regular monitoring. Wysolone 5 may also cause decreased bone mineral density, if used for long periods. Long term use of steroids may be associated with a range of side effects such as round face, altered body shape, altered hair growth, thinning of the bones, decreased resistance to infection, increased salt and water retention, increased blood pressure and diabetes.

When should Wysolone not be used?

You should not use Wysolone 5 if you:

are allergic to prednisolone or any ingredients in Wysolone
are pregnant or are breastfeeding
have thyroid, stomach, heart, kidney or liver problems, high blood pressure, mood disorders, epilepsy, diabetes, glaucoma, osteoporosis
have any infectious disease, acute infection, systemic fungal infection, tuberculosis, uncomplicated viral hepatitis
are due to receive a vaccination with a live virus vaccine
are taking medicines that interact with Wysolone like anti-inflammatories such as; diclofenac, ibuprofen, mefenamic acidor naproxen; barbiturates, phenylbutazone, phenytoin or rifampicin, anticoagulants, insulin for diabetes
are taking diuretic medicines such as the thiazides or frusemide, these may cause increased loss of potassium when taken with Wysolone 5

What medications interact with Wysolone?

Several medications interact with Wysolone and should either not be taken while you are taking Wysolone or only after discussion and instruction from your doctor:

Drugs that cause a serious reaction with Wysolone: anti-inflammatories such as; diclofenac, ibuprofen, mefenamic acidor naproxen
Drugs that affect Wysolone: rifampicin, barbiturates, phenylbutazone, phenytoin
Drugs that are affected by Wysolone: live virus vaccine may be less effective, anticoagulants, insulin for diabetes

How should Wysolone be taken?

You should take your Wysolone tablets 5mg swallowed whole with a glass of water and with food. The dose of Wysolone 5 that you take, how often and for how long depends on what you are being treated for and as recommended by your doctor. You should continue to take your Wysolone 5 for as long as recommended by your doctor and should not stop taking them suddenly; withdrawal should be gradual to reduce risk of side effects.

How long should you take Wysolone?

You should continue to take your Wysolone 5 for as long as recommended by your doctor and should not stop taking them suddenly; withdrawal should be gradual to reduce risk of side effects.

Missed dose of Wysolone

If you miss a dose of Wysolone 5 take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.

How should Wysolone be stored?

You should store your Wysolone below 25°C in a cool dry place.

TEST2

Shipping delays due to Covid-19 Virus