Nausicalm (Cyclizine Hydrochloride 50mg) 10 Tablets/pack

Nausicalm general information 


What is Nausicalm Tablet used for?

Nausicalm Tablet 50mg is an anti-emetic used to treat and prevent nausea and vomiting caused by a range of clinical situations including motion sickness, following surgery to prevent post-operative vomiting due to anaesthetics and narcotic analgesics, vertigo (giddiness/dizziness) associated with middle ear problems, including Meniere's disease, and nausea and vomiting associated with radiation treatment for cancer, especially breast cancer. 

How does Nausicalm Tablet work?

Nausicalm Tablet contains cyclizine 50mg, an antiemetic and piperazine derivative antihistamine with H1-receptor antagonist properties; also antimuscarinic and anticholinergic activity. Cyclizine in Nausicalm Tablet 50mg binds to the H1 histamine receptor found on smooth muscle cells and on the vascular endothelial cells lining blood vessels; it is also found in the central nervous system. Cyclizine in Nausicalm tablet 50mg also binds to muscarinic receptors, which are receptors for acetylcholine, a neurotransmitter that acts in the brain and central nervous system.  Nausea and vomiting are triggered when the chemoreceptor trigger zone (CTZ) in the brain is stimulated and this causes nerve impulses to be sent to area postrema or vomiting centre of the brain, to induce the vomiting reflex. The CTZ can be activated by two mechanisms; either indirectly by transmission of nerve impulses sent to the brain from the stomach when it has been irritated, or directly by chemicals or drugs that are circulating in the blood and stimulate receptors in the brain.  Cyclizine in Nausicalm tablet 50mg is thought to act by blocking the muscarinic receptors in brainstem areas regulating emesis (vomiting), thereby blocking transmission of nerve messages to the vomiting centre in the brain.  H1 receptors are also found in the stomach and the CZT and may also be involved in blocking emesis.  The combined actions of Cyclizine in Nausicalm tablet 50mg prevents vomiting and relieves feelings of nausea due to a variety of causes.  Nausicalm tablet 50mg starts working within 30-60 minutes and the effects last for 4-6 hours, sometimes longer.  

What does Nausicalm Tablet contain?

Nausicalm Tablet contains the active ingredient cyclizine hydrochloride 50mg used to treat and prevent nausea and vomiting due to various clinical conditions. It is a white, circular, uncoated tablet with a score line on one side and plain on the other. The tablet can be divided into two halves. 

Treating nausea with Nausicalm Tablet

Nausicalm Tablet 50mg contains cyclizine, an antiemetic and antihistamine with H1-receptor antagonist properties; also antimuscarinic and anticholinergic activity, but it is non-sedating as it does not cross the blood brain barrier.  Nausicalm tablet 50mg is used as an anti-emetic used to treat and prevent nausea and vomiting caused by a range of clinical situations including motion sickness, following surgery to prevent post-operative vomiting due to anaesthetics and narcotic analgesics, vertigo (giddiness/dizziness) associated with middle ear problems, including Meniere's disease, and nausea and vomiting associated with radiation treatment for cancer. Cyclizine in Nausicalm tablet 50mg is thought to have several mechanisms of action, including increasing lower oesophageal sphincter tone and reducing the sensitivity of the labyrinthine apparatus in the middle ear, which may contribute to reducing nausea.  Cyclizine in Nausicalm tablet 50mg is also thought to act directly on the vomiting centre of the brain by blocking the receptors for neurotransmitters that stimulate the vomiting reflex. 

What are the side effects of Nausicalm Tablet?

The most commonly reported side effects when taking Nausicalm Tablet include, blurred vision, oculogyric crisis (involuntary eye movement), tachycardia (rapid heartbeat) palpitations, arrhythmias, dryness of the mouth, nose and throat, constipation, increased gastric reflux, nausea, vomiting, diarrhoea, stomach pain, loss of appetite, urinary retention, twitching, muscle spasms, somnolence, headache, dystonia, dyskinesia (involuntary movements), extrapyramindal motor disturbances, tremor, convulsions, dizziness, decreased consciousness, transient speech disorders, paraesthesia, dyskinesia, disorientation, agitation, breathing problems (bronchospasm, apnoea), skin reactions (urticaria, drug rash, angioedema), hypertension, hypotension.

When should Nausicalm Tablet not be used?

You should not use Nausicalm Tablet 50mg if you:

• are allergic to cyclizine or any ingredients in Nausicalm Tablet
• are pregnant or are breastfeeding
• have kidney or liver disease
• have glaucoma, intestinal obstruction, epilepsy or prostate disease
• have severe heart failure
• are taking medicines that interact with Nausicalm Tablet, including alcohol and other central nervous system depressants such as hypnotics, tranquillisers, anaesthetics, antipsychotics, barbiturates, pethidine; aminoglycoside antibacterials, other anticholinergics for treating urinary incontinence, irritable bowel syndrome and Parkinson's disease

What medications interact with Nausicalm Tablet?

Several medications interact with Nausicalm Tablet and should either not be taken while you are taking Nausicalm Tablet or only after discussion and instruction from your doctor:

• Drugs that cause a serious reaction with Nausicalm Tablet: other anticholinergics for treating urinary incontinence, irritable bowel syndrome and Parkinson's disease due to enhanced side effects; aminoglycoside antibacterials by masking toxic effects on the ear
• Drugs that are affected by Nausicalm Tablet: pethidine, alcohol and other central nervous system depressants such as hypnotics, tranquillisers, anaesthetics, antipsychotics, barbiturates due to an additive effect

How should Nausicalm Tablet be taken?

Nausicalm Tablet 50mg should be taken as follows

Adults and children over 12 years: One tablet (50mg) up to three times daily.

Children 6-12 years: Half a tablet (25mg) up to three times daily.

Children under 6 years: Not recommended.

Use in hepatic impairment: Use with caution and monitor closely in patients with hepatic disease. 

The dose you are given and when is determined by what you are being treated for, and your Healthcare providers recommendation.

How long should you take Nausicalm Tablet?

Nausicalm tablet is used for short-term relief- in general 1 – 3 days.

It is designed as an intermittent or occasional use, and not as long-term daily medication.

If nausea persists consult your Healthcare provider.

How should Nausicalm Tablet be stored?

You should store your Nausicalm Tablets below 25°C in a cool dry place and protect from light.