Your Country: ?
Your Currency: ?
CONTACT US
USA: 877-756-4701
UK: 0808 234 9722
Outside UK/USA: 1 877 756 4701
Your Country: ?
Your Currency: ?
Login | SHOPPING CART    (0 items)
USA: 877-756-4701
UK: 0808 234 9722
Outside UK/USA: 1 877 756 4701
Your Country: ?
Your Currency: ?
Login | SHOPPING CART    (0 items)
FREE SHIPPING TO UNITED STATES
Janumet (Sitagliptin Phosphate & Metformin Hydrochloride 50mg/1000mg) 15 Tablets/Strip


Janumet (Sitagliptin Phosphate & Metformin Hydrochloride 50mg/1000mg) 15 Tablets/Strip

Janumet (Sitagliptin Phosphate & Metformin Hydrochloride 50mg/1000mg)


Product Name
Janumet (Sitagliptin Phosphate & Metformin Hydrochloride 50mg/1000mg) 15 Tablets/Strip
Active Ingredient
Sitagliptin Phosphate & Metformin Hydrochloride
Manufacturer
Merck Sharp & Dohme
Product Type
Antihyperglycaemic
Product expiry date we are currently shipping
Discontinued, no stock

This product has been discontinued and we currently do not have an alternative available at this time.

Janumet tablets 50/1000mg contain a fixed dose combination of two oral antihypergylycaemic medications, sitagliptin and metformin that work together to improve glycaemic control in Type 2 Diabetes Mellitus. 

Janumet general information

What is Janumet used for?

Janumet tablets 50/1000mg are used to treat Type 2 Diabetes Mellitus (T2DM), to improve glycaemic control (control of blood sugar levels).  T2DM (also known as non-insulin-dependent diabetes) is a disease characterised by high blood sugar levels that are difficult to control (poor glycaemic control).  Loss of glycaemic control can be due to chronic damage to the beta cells of the pancreas and loss of their normal function, which is the production of insulin in response to increase in blood glucose, such as following a meal; also insulin resistance is another reason for poor glycaemic control in T2DM.  Janumet tablets 50/1000mg are used as an adjunct to (in addition to) diet and exercise, in those who are not adequately controlled by a single medication alone or who are already being treated with each medication separately; for triple therapy with a sulphonylurea, a third type of antihypergylycaemic medication in those who are not adequately controlled by using two medications; also in combination with long/intermediate acting insulin.  Janumet tablets 50/1000mg help lower high blood sugar levels, particularly after a meal, keep blood sugar levels down between meals and reduce the amount of sugar made in the liver.  This restores glycaemic control and helps prevent or delay the development of serious complications of T2DM.  These include cardiovascular disease leading to heart attack and stroke.  Also microvascular damage (damage to capillaries) in the eye, kidney or nerves can lead to diabetic retinopathy, nephropathy or neuropathy, which contributes to blindness, kidney disease, foot ulcers.  In extreme cases microvascular damage can result in amputation.

How does Janumet work?

Janumet tablets 50/1000mg contain a fixed dose combination of two oral antihypergylycaemics, sitagliptin and metformin that work together to improve glycaemic control in T2DM.

Sitagliptin in Janumet tablets 50/1000mg is a potent and selective inhibitor of the enzyme dipeptidyl peptidase 4 (DPP-4) and works by preventing the breakdown of two small proteins called incretins.  These incretins, Glucose-dependent Insulinotropic Polypeptide (GIP) is and Glucagon-Like Peptide-1 (GLP-1) are involved in the regulation of glucose homeostasis (maintaining normal glucose levels).  They are released from the intestine in response to increased glucose levels, particularly following food ingestion, and stimulate glucose-dependent insulin production from the pancreatic beta cells to lower blood glucose levels; as well as suppressing glucagon release from the pancreatic alpha cells to reduce glucose production in the liver.  However, the incretins are normally rapidly degraded by DPP-4 into inactive metabolites.  Sitagliptin in Janumet tablets 50/1000mg inhibits this degradation, thereby increasing incretin levels, allowing them to be active for longer so that they can continue to restore blood glucose to normal levels.  This process is glucose-dependent and is only activated when glucose levels are raised and therefore, unlike other anti-diabetic medications, does not lead to hypoglycaemia (low blood sugar), which is a potentially serious side effect. 

Metformin in Janumet tablets 50/1000mg is an oral antihyperglycaemic medication belonging to the biguanide group of drugs and controls blood glucose by lowering levels of glucose after a meal (posprandial) as well as keeping levels normal between meals (basal levels); it also helps the body respond to insulin without increasing insulin production.  Metformin in Janumet tablets 50/1000mg works using three different mechanisms: decreasing glucose production in the liver, which is normally switched off when blood glucose levels are high enough; increasing sensitivity to insulin in fat and muscle tissue, where excess glucose is removed from the blood and stored; reducing absorption of glucose from the diet by the intestines.   

The combination of sitagliptin and metformin in Janumet tablets 50/1000mg work together to reduce hyperglycaemia and restores glycaemic control in patients with T2DM.

What does Janumet contain?

Janumet tablets contain the active ingredients sitagliptin phosphate 50mg and metformin hydrochloride 1000mg that work together to lower blood glucose levels and restore glycaemic control in patients with T2DM.  They also contain microcrystalline cellulose, polyvinylpyrrolidone, sodium lauryl sulfate, and sodium stearyl fumarate; also polyvinyl alcohol, polyethylene glycol, talc, titanium dioxide, red iron oxide, and black iron oxide in the film coating.

Treating Type-2 Diabetes with Janumet

Janumet tablets 50/1000mg contain a fixed dose combination of sitagliptin and metformin, two oral antihypergylycaemic medications that are used to treat Type 2 Diabetes Mellitus (T2DM), to improve glycaemic control (control of blood sugar levels).  T2DM (also known as non-insulin-dependent diabetes) is a disease characterised by high blood sugar levels that are difficult to control (poor glycaemic control).  Loss of glycaemic control can be due to chronic damage to the beta cells of the pancreas and loss of their normal function, which is the production of insulin in response to increase in blood glucose, such as following a meal; also insulin resistance is another reason for poor glycaemic control in T2DM.  Sitagliptin in Janumet tablets 50/1000mg is a potent and selective inhibitor of the enzyme dipeptidyl peptidase 4 (DPP-4) and works by preventing the breakdown of two small proteins called incretins that are released from the intestine in response to increased glucose levels, particularly following food ingestion.  Incretins stimulate glucose-dependent insulin production from the pancreatic beta cells to lower blood glucose levels; as well as suppressing glucagon release from the pancreatic alpha cells to reduce glucose production in the liver. 

Metformin in Janumet tablets 50/1000mg controls blood glucose by lowering glucose levels after a meal (posprandial), keeping levels normal between meals (basal levels) and improving the response to insulin without increasing insulin production.  It works using three different mechanisms: decreasing glucose production in the liver, which is normally switched off when blood glucose levels are high enough; increasing sensitivity to insulin in fat and muscle tissue, where excess glucose is removed from the blood and stored; reducing absorption of glucose by the intestines from the diet.  Janumet tablets 50/1000mg can be used as monotherapy or in combination with other antidiabetic medications.  Janumet tablets 50/1000mg helps prevent or delay the development of serious complications of T2DM.  These include cardiovascular disease leading to heart attack and stroke.  Also microvascular damage (damage to capillaries) in the eye, kidney or nerves can lead to diabetic retinopathy, nephropathy or neuropathy, which contributes to blindness, kidney disease, foot ulcers.  In extreme cases microvascular damage can result in amputation.

What are the side effects of Janumet?

The most commonly reported side effects when taking Janumet tablets 50/1000mg that are due to sitagliptin include, gastrointestinal upset (nausea, diarrhoea, indigestion, flatulence, vomiting) headache, upper respiratory infection, stuffy or runny nose and sore throat, cough, fungal skin infection, peripheral oedema (swelling of the hands or leg).  The most commonly reported side effects when taking Janumet that are due to metformin include, gastrointestinal symptoms (such as diarrhoea, nausea, vomiting) which are usually mild and resolve spontaneously during continued treatment, metallic taste in the mouth and skin rash.  A rare but potentially life threatening side effect of metformin is lactic acidosis (a build-up of lactic acid in the blood) that can occur due to accumulation of metformin, particularly if you are taking high doses of metformin above 2000mg per day, have kidney problems, drink excessive amounts of alcohol or are elderly.

When should Janumet not be used?

You should not use Janumet tablets 50/1000mg if you:

  • are allergic to sitagliptin, metformin or any ingredients in Janumet
  • are pregnant or are breastfeeding
  • have kidney or liver disease
  • have type 1 diabetes or diabetic ketoacidosis
  • have symptoms of pancreatitis while taking Janumet, including severe persistent stomach pain, with or without vomiting
  • have acute or chronic disease which may cause tissue hypoxia such as congestive heart failure, recent myocardial infarction, respiratory failure, pulmonary embolism, shock, acute significant blood loss, sepsis
  • are over 80 without discussion with your doctor
  • have a problem with alcohol
  • are undergoing radiological treatment with intravascular iodinated contrast agents which may lead to renal failure, resulting in metformin accumulation and a risk of lactic acidosis
  • are taking medicines that interact with Janumet, including digoxin for heart failure, thiazide diuretics and other diuretics like furosemide, calcium channel blockers like nifedipine for blood pressure and heart conditions, cimetidine for reflux and ulcers, corticosteroids such as prednisone, thyroid products, oral contraceptives, oestrogens, the anticonvulsant phenytoin, antiphsychotic phenothiazines, nicotinic acid for high cholesterol, the antibiotic isoniazid, beta blockers like propranolol for heart conditions and high blood pressure

What medications interact with Janumet?

Several medications interact with Janumet tablets 50/1000mg and should either not be taken while you are taking Janumet or only after discussion and instruction from your doctor:

  • Drugs that cause a serious reaction with Janumet: alcohol can increase the effect of metformin on lactic acid metabolism; corticosteroids such as prednisone, thyroid products, oral contraceptives oestrogens, the anticonvulsant phenytoin, antiphsychotic phenothiazines, nicotinic acid for high cholesterol, the antibiotic isoniazid, beta blockers like propranolol for heart conditions and high blood pressure may lead to loss of glycaemic control
  • Drugs that affect Janumet: thiazide diuretics and other diuretics like furosemide, calcium channel blockers like nifedipine for blood pressure and heart conditions, cimetidine for reflux and ulcers
  • Drugs that are affected by Janumet: digoxin for heart failure, diuretics like furosemide

How should Janumet be taken?

You should take your Janumet tablets 50/1000mg swallowed whole with a glass of water, twice daily with food.  The dose you take may be increased and you may also be taking other medications including a sulphonylurea and/or insulin, depending on your doctor’s recommendation and how well your blood sugar level is controlled.  You should continue to take your Janumet tablets 50/1000mg for as long as recommended by your doctor, which may be for long periods.

How long should you take Janumet?

You should continue to take your Janumet tablets 50/1000mg for as long as recommended by your doctor, which may be for long periods.

Missed dose of Janumet

If you miss a dose of Janumet tablets 50/1000mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose.  Do not take a double dose.

How should Janumet be stored?

You should store your Janumet tablets 50/1000mg below 25°C in a cool dry place. 

 

 

See more products in
    All medicines have risks and benefits, and individual results may vary. Only purchase medicines from this site in accordance with the advice you have obtained from an appropriate medical professional.
    What is this ?
    Please select your country to display all the products we are able to supply to you.
    What is this ?
    Select the currency that you would like to display the prices in. This will be the currency that appears on your credit card statement.
     

    This website uses cookies. View our policy and select your preferences here