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Angiotensin II Receptor Blocker (ARB)

Our Angiotensin II receptor blockers class of Heart Health medications are used to treat hypertension (high blood pressure) to prevent heart attack and stroke; also to treat and heart failure and help relieve symptoms.  

Use the search feature to quickly find the product you are looking for, by entering either the active ingredient, e.g. candesartan or the product name, e.g. Candesar-8. 

Our Angiotensin II receptor blockers class of Heart Health medications are used to treat hypertension (high blood pressure) to prevent heart attack and stroke; also to treat and heart failure and help relieve symptoms.  

Use the search feature to quickly find the product you are looking for, by entering either the active ingredient, e.g. candesartan or the product name, e.g. Candesar-8. 
...Read more

Candestar (Candesartan) 32mg
Candestar (Candesartan) 32mg
On Sale

Candesartan
Also known as Atacand, Diceran, Blopress, Amias & Ratacand
From $0.59 per Tablet
Cosart-H (Losartan Potassium & Hydrochlorthiazide 50mg/12.5mg) Tablets
Cosart-H (Losartan Potassium & Hydrochlorthiazide 50mg/12.5mg) Tablets

Losartan Potassium & Hydrochlorthiazide
Also known as Hyzaar
Out Of Stock
Losartan Actavis 12.5mg
Losartan Actavis 12.5mg

Losartan
Also known as Cozaar
From $0.39 per Tablet
Olmecip H (Olmesartan & hydrochlorothiazide) 40mg/12.5mg
Olmecip H (Olmesartan & hydrochlorothiazide) 40mg/12.5mg
On Sale

Olmesartan and hydrochlorothiazide
Also known as Benicar HCT
From $0.40 per Tablet
Losartan Actavis 50mg
Losartan Actavis 50mg

Losartan
Also known as Cozaar
From $0.55 per Tablet
Olmecip 40mg (Olmesartan)
Olmecip 40mg (Olmesartan)

Olmesartan
Also known as Benicar
From $0.90 per Tablet
Losartan Actavis 100mg
Losartan Actavis 100mg

Losartan
Also known as Cozaar
From $0.61 per Tablet
Olmezest 20mg (Olmesartan)
Olmezest 20mg (Olmesartan)

Olmesartan
Also known as Benicar
From $0.63 per Tablet
Olmezest H 20 (Olmesartan/HCTZ) 100's
Olmezest H 20 (Olmesartan/HCTZ) 100's

Olmesartan 20mg/hydrochlorothiazide 12.5mg
Also known as Benicar HCT
From $0.86 per Tablet
Olmecip H (Olmesartan and hydrochlorothiazide 20mg/12.5mg)
Olmecip H (Olmesartan and hydrochlorothiazide 20mg/12.5mg)

Olmesartan and hydrochlorothiazide
Also known as Benicar HCT
From $0.63 per Tablet
Telsartan-40 (Telmisartan 40mg) 14s
Telsartan-40 (Telmisartan 40mg) 14s
On Sale

Telmisartan IP
Also known as Micardis
Telsartan-80 (Telmisartan 80mg) 14s
Telsartan-80 (Telmisartan 80mg) 14s

Telmisartan IP
Also known as Micardis
From $1.11 per Tablet
Valzaar-H 80-12.5mg (Valstartan/Hydrochlorthiazide)
Valzaar-H 80-12.5mg (Valstartan/Hydrochlorthiazide)

Valstartan/Hydrochlorthiazide
Also known as Diovan HCT
From $0.92 per Capsule
Valzaar 160mg (Valsartan)
Valzaar 160mg (Valsartan)

Valsartan
Also known as Diovan
From $1.20 per Tablet
Valzaar 80mg  (Valsartan)
Valzaar 80mg (Valsartan)

Valsartan
Also known as Diovan
From $0.90 per Tablet
Zaart-H 50mg/12.5mg
Zaart-H 50mg/12.5mg

Losartan Potassium & Hydrochlorthiazide
Also known as Hyzaar
Out Of Stock

What is angiotensin?

Angiotensin is a naturally produced hormone that forms part of a complex interaction of hormones, known as the renin-angiotensin hormone system that regulates blood volume, body fluid levels and blood pressure.  Angiotensin is produced by the liver as angiotensinogen, which is converted to angiotensin I by the action of renin, released by the kidney when blood pressure and volume is low.  Angiotensin I is the inactive precursor for Angiotensin II, which is produced by the action of Angiotensin Converting Enzyme (ACE) mainly in the lungs, but also in the kidney and endothelial cells lining the blood vessels. 

Angiotensin II is a highly vasoactive hormone that has potent effects on blood pressure and fluid balance.  It stimulates vascular smooth muscle to contract, which causes blood vessels to constrict (narrow).  This increases blood volume while at the same time reducing blood vessel volume, which increases blood pressure.  Angiotensin II also stimulates the production of the hormone aldosterone from the adrenal gland.  Aldosterone stimulates the tubule cells of the kidney to reabsorb salt (sodium and potassium) and water from the blood, which also increase blood volume and pressure.

ACE also degrades the enzyme bradykinin, which is a potent vasoldilator, and this action of ACE further increases blood pressure.  

Angiotensin II receptor

The binding of Angiotensin II to the Angiotensin receptor (AR) activates the receptor and this mediates all the actions of Angiotensin II via a series of trans-membrane and intracellular signal transduction systems, including activation or inhibition of enzymes (activation of phospholipases C and A2 and tyrosine kinases, inhibition of adenylate cyclase) and opening of calcium channels.

The Angiotensin II receptor is widely distributed and is found on the cells of many organs and tissues of the body, including the heart, blood vessel walls, kidney, adrenal gland, lung and brain.  The consequences of activating the AR depend on which tissue the receptor is located in.  In the cortex of the adrenal gland, activation of the AR by Angiotensin II stimulates the release of aldosterone, which in turn stimulates the reuptake of salt and water in the kidney.  In the heart muscle, it causes cardiac hypertrophy or growth, which is a pathological condition associated with high blood pressure.  In the vascular smooth muscle of blood vessel walls it causes vasoconstriction and narrowing of the blood vessels, which contributes to increased blood pressure. 

Angiotensin II receptor blockers for hypertension and heart failure

The angiotensin receptor (AR) is a target for antihypertensive drugs since blocking the receptor also blocks all the actions of Angiotensin II that happen as a result of activation of the AR.  Angiotensin receptor blockers (ARBs) cause vasodilation or widening of the blood vessels, which reduces blood pressure.  They also reduce the production of aldosterone, which reduces uptake of salt and water by the kidneys, blood volume and fluid retention in the tissues, and therefore, ARBs are suitable for treating congestive heart failure. 

Unlike ACE inhibitors, ARBs do not prevent the degradation of bradykinin, which further lowers blood pressure but also causes persistent dry cough as a side effect due to bradykinin.  Therefore, ARBs are often used for those intolerant to ACE inhibitors.  
...Read more

What is angiotensin?

Angiotensin is a naturally produced hormone that forms part of a complex interaction of hormones, known as the renin-angiotensin hormone system that regulates blood volume, body fluid levels and blood pressure.  Angiotensin is produced by the liver as angiotensinogen, which is converted to angiotensin I by the action of renin, released by the kidney when blood pressure and volume is low.  Angiotensin I is the inactive precursor for Angiotensin II, which is produced by the action of Angiotensin Converting Enzyme (ACE) mainly in the lungs, but also in the kidney and endothelial cells lining the blood vessels. 

Angiotensin II is a highly vasoactive hormone that has potent effects on blood pressure and fluid balance.  It stimulates vascular smooth muscle to contract, which causes blood vessels to constrict (narrow).  This increases blood volume while at the same time reducing blood vessel volume, which increases blood pressure.  Angiotensin II also stimulates the production of the hormone aldosterone from the adrenal gland.  Aldosterone stimulates the tubule cells of the kidney to reabsorb salt (sodium and potassium) and water from the blood, which also increase blood volume and pressure.

ACE also degrades the enzyme bradykinin, which is a potent vasoldilator, and this action of ACE further increases blood pressure.  

Angiotensin II receptor

The binding of Angiotensin II to the Angiotensin receptor (AR) activates the receptor and this mediates all the actions of Angiotensin II via a series of trans-membrane and intracellular signal transduction systems, including activation or inhibition of enzymes (activation of phospholipases C and A2 and tyrosine kinases, inhibition of adenylate cyclase) and opening of calcium channels.

The Angiotensin II receptor is widely distributed and is found on the cells of many organs and tissues of the body, including the heart, blood vessel walls, kidney, adrenal gland, lung and brain.  The consequences of activating the AR depend on which tissue the receptor is located in.  In the cortex of the adrenal gland, activation of the AR by Angiotensin II stimulates the release of aldosterone, which in turn stimulates the reuptake of salt and water in the kidney.  In the heart muscle, it causes cardiac hypertrophy or growth, which is a pathological condition associated with high blood pressure.  In the vascular smooth muscle of blood vessel walls it causes vasoconstriction and narrowing of the blood vessels, which contributes to increased blood pressure. 

Angiotensin II receptor blockers for hypertension and heart failure

The angiotensin receptor (AR) is a target for antihypertensive drugs since blocking the receptor also blocks all the actions of Angiotensin II that happen as a result of activation of the AR.  Angiotensin receptor blockers (ARBs) cause vasodilation or widening of the blood vessels, which reduces blood pressure.  They also reduce the production of aldosterone, which reduces uptake of salt and water by the kidneys, blood volume and fluid retention in the tissues, and therefore, ARBs are suitable for treating congestive heart failure. 

Unlike ACE inhibitors, ARBs do not prevent the degradation of bradykinin, which further lowers blood pressure but also causes persistent dry cough as a side effect due to bradykinin.  Therefore, ARBs are often used for those intolerant to ACE inhibitors.  
...Read more

All medicines have risks and benefits, and individual results may vary. Only purchase medicines from this site in accordance with the advice you have obtained from an appropriate medical professional.
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