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Outside UK/USA: 1 877 756 4701
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Nerve Pain Treatments
Our Nerve Pain class of Pain medications contain anticonvulsant drugs used to relieve nerve pain, which is caused by a damaged or malfunctioning nervous system.

Use the search feature to quickly find the product you are looking for, by entering either the active ingredient, e.g. sodium valproate, or the product name, e.g. Epilim.

...Read more
Our Nerve Pain class of Pain medications contain anticonvulsant drugs used to relieve nerve pain, which is caused by a damaged or malfunctioning nervous system.

Use the search feature to quickly find the product you are looking for, by entering either the active ingredient, e.g. sodium valproate, or the product name, e.g. Epilim.

...Read more

APO-Gabapentin 100mg
APO-Gabapentin 100mg

Gabapentin
Also known as Neurontin
From $0.21 per Capsule
APO-Gabapentin 300mg
APO-Gabapentin 300mg

Gabapentin
Also known as Neurontin
From $0.40 per Capsule
APO-Gabapentin 400mg
APO-Gabapentin 400mg

Gabapentin
Also known as Neurontin
From $0.52 per Capsule
Epilim EC 500mg
Epilim EC 500mg
Sodium Valproate
Sodium Valproate
From $0.93 per Tablet
Neurontin  (Gabapentin) 100mg
Neurontin (Gabapentin) 100mg
Gabapentin
From $0.27 per Tablet
Neurontin  (Gabapentin) 300mg
Neurontin (Gabapentin) 300mg
Gabapentin
Out Of Stock
Neurontin  (Gabapentin) 400mg
Neurontin (Gabapentin) 400mg
Gabapentin
From $0.80 per Capsule
Tegretol 200mg 100 Tabs
Tegretol 200mg 100 Tabs
On Sale
Carbamazepine
From $0.19 per Tablet
Tegretol 400mg
Tegretol 400mg
Carbamazepine
From $0.68 per Tablet
Topiramate 25mg Actavis
Topiramate 25mg Actavis

Topiramate
From $0.68 per Tablet
Tegretol CR 200mg
Tegretol CR 200mg
Carbamazepine
From $0.35 per Tablet
Tegretol CR 400mg
Tegretol CR 400mg
Carbamazepine
From $0.78 per Tablet
Topiramate 100mg
Topiramate 100mg

Topiramate
From $1.50 per Tablet
Tegrital (Carbamazepine 200mg)
Tegrital (Carbamazepine 200mg)
Carbamazepine
Also known as Tegretol (and made by same manufacturer)
Discontinued
Tegrital (Carbamazepine 400mg)
Tegrital (Carbamazepine 400mg)
Carbamazepine
Also known as Tegretol (and made by same manufacturer)
From $0.48 per Tablet
Tegrital CR (Carbamazepine 200mg)
Tegrital CR (Carbamazepine 200mg)
Carbamazepine
Also known as Tegretol (and made by same manufacturer)
From $0.25 per Tablet
Tegrital CR (Carbamazepine 400mg)
Tegrital CR (Carbamazepine 400mg)
On Sale
Carbamazepine
Also known as Tegretol (and made by same manufacturer)
From $0.28 per Tablet
Topamax 50mg  (Topiramate)
Topamax 50mg (Topiramate)
Topiramate
From $1.77 per Tablet
Topiramate 50mg Actavis
Topiramate 50mg Actavis

Topiramate
From $1.17 per Tablet

What is nerve pain

Nerve pain or neuropathic pain is caused by damage to or malfunction of the peripheral or central nervous system. The initial trigger may be an injury such as loss of a limb; exposure of nerves to chemotherapy; inflammation of a nerve due to infection, sensitisation of a nerve following injury, such as disc damage; post-herpetic neuralgia (shingles) caused by nerve damage, where virus travels along the nerve and causes sensitisation, nerve entrapment as in carpel tunnel syndrome or strangulation by scar tissue. Nerve pain is usually chronic and persists long after the initial injury has healed. The pain becomes a central nervous system problem and can be stimulated without any apparent injury, by sub-threshold pain stimuli or just by increased perception. The pain felt is described as electric shocks, stabbing or burning pain.

Treatments for nerve pain

Treatments for nerve pain are based on the understanding that this type of pain is due to loss of normal control within the central nervous system in a way that is comparable to epilepsy. This is why medications that interact directly with the brain are often used as first line therapy, including anticonvulsants; also muscle relaxants and antidepressants are used in some cases.

Anti-convulsants

Anticonvulsant drugs are used to treat nerve pain because they help control the bursts of electrical activity in the brain that cause nerve pain. They work by preventing the repetitive firing of nerve messages (electrical and chemical) acting through different mechanisms, including; blocking sodium channels that are involved in setting up a nerve signal, blocking calcium channels that respond to a nerve signal and trigger the release of neurotransmitters, adjusting the balance between inhibitory and excitatory neurotransmitters, or a combination of these mechanisms.

For the brain to function normally it is important to have a balance between excitatory and inhibitory neurotransmitters. Glutamate is the major excitatory neurotransmitter and interacts with receptors that have excitatory effects, which means that they increase the probability that the target cell will set up an action potential and trigger a nerve signal. Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter and interacts with receptors that have inhibitory effects by failing to trigger a nerve signal and this has a calming effect on nerve cells. Anti-convulsants that are used for nerve pain include:
  • Gabapentin, a GABA analogue that is thought to control neurotransmission via voltage-gated calcium channels, which reduces the propagation of excitatory nerve transmissions and calms excitatory nerve cells, reducing nerve pain intensity.

  • Carbamazepine and topiramate block sodium channels in nerve cell membranes that control the flow of sodium ions into the nerve cell and triggers an electrical transmission. This reduces the neurone’s ability to send out continuous signals reducing nerve pain intensity.

  • Sodium valproate that works by increasing the activity of the inhibitory neurotransmitter GABA; also by preventing the reuptake of GABA by the pre-synaptic nerve cell Sodium valproate acts as a nerve cell membrane stabiliser by blocking voltage-dependent sodium channels.
...Read more

What is nerve pain

Nerve pain or neuropathic pain is caused by damage to or malfunction of the peripheral or central nervous system. The initial trigger may be an injury such as loss of a limb; exposure of nerves to chemotherapy; inflammation of a nerve due to infection, sensitisation of a nerve following injury, such as disc damage; post-herpetic neuralgia (shingles) caused by nerve damage, where virus travels along the nerve and causes sensitisation, nerve entrapment as in carpel tunnel syndrome or strangulation by scar tissue. Nerve pain is usually chronic and persists long after the initial injury has healed. The pain becomes a central nervous system problem and can be stimulated without any apparent injury, by sub-threshold pain stimuli or just by increased perception. The pain felt is described as electric shocks, stabbing or burning pain.

Treatments for nerve pain

Treatments for nerve pain are based on the understanding that this type of pain is due to loss of normal control within the central nervous system in a way that is comparable to epilepsy. This is why medications that interact directly with the brain are often used as first line therapy, including anticonvulsants; also muscle relaxants and antidepressants are used in some cases.

Anti-convulsants

Anticonvulsant drugs are used to treat nerve pain because they help control the bursts of electrical activity in the brain that cause nerve pain. They work by preventing the repetitive firing of nerve messages (electrical and chemical) acting through different mechanisms, including; blocking sodium channels that are involved in setting up a nerve signal, blocking calcium channels that respond to a nerve signal and trigger the release of neurotransmitters, adjusting the balance between inhibitory and excitatory neurotransmitters, or a combination of these mechanisms.

For the brain to function normally it is important to have a balance between excitatory and inhibitory neurotransmitters. Glutamate is the major excitatory neurotransmitter and interacts with receptors that have excitatory effects, which means that they increase the probability that the target cell will set up an action potential and trigger a nerve signal. Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter and interacts with receptors that have inhibitory effects by failing to trigger a nerve signal and this has a calming effect on nerve cells. Anti-convulsants that are used for nerve pain include:
  • Gabapentin, a GABA analogue that is thought to control neurotransmission via voltage-gated calcium channels, which reduces the propagation of excitatory nerve transmissions and calms excitatory nerve cells, reducing nerve pain intensity.

  • Carbamazepine and topiramate block sodium channels in nerve cell membranes that control the flow of sodium ions into the nerve cell and triggers an electrical transmission. This reduces the neurone’s ability to send out continuous signals reducing nerve pain intensity.

  • Sodium valproate that works by increasing the activity of the inhibitory neurotransmitter GABA; also by preventing the reuptake of GABA by the pre-synaptic nerve cell Sodium valproate acts as a nerve cell membrane stabiliser by blocking voltage-dependent sodium channels.
...Read more

All medicines have risks and benefits, and individual results may vary. Only purchase medicines from this site in accordance with the advice you have obtained from an appropriate medical professional.
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