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APO-Leflunomide (Leflunomide 20mg) 30 Tablets/Pack


APO-Leflunomide (Leflunomide 20mg) 30 Tablets/Pack

APO-Leflunomide 20mg

 

Product Name
APO-Leflunomide (Leflunomide 20mg) 30 Tablets/Pack
Also known as Arava
Active Ingredient
Leflunomide
Manufacturer
Apotex
Product Type
Antirheumatic
Product expiry date we are currently shipping
Apr 2020
Product Price List
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APO-Leflunomide 20mg 30 Tablets
$1.50 per Tablet
|
$45.00 (USD) 
$45.00 (USD) 
APO-Leflunomide 20mg 60 Tablets
$1.35 per Tablet
|
$81.00 (USD) 
$81.00 (USD) 
APO-Leflunomide 20mg 90 Tablets
$1.25 per Tablet
|
$112.50 (USD) 
$112.50 (USD) 

APO-Leflunomide tablets 20mg contain leflunomide, a disease-modifying antirheumatic drug (DMARD) that is used to relieve inflammatory symptoms of arthritic diseases like rheumatoid arthritis and active psoriatic arthritis, including join pain, swelling and redness. 

APO-Leflunomide general information

What is APO-Leflunomide used for?

APO-Leflunomide tablets 20mg are used to treat rheumatoid arthritis and active psoriatic arthritis, which are both autoimmune disorders (when the immune system attacks self), have an overactive immune system and have a genetic predisposition.  Rheumatoid arthritis is a chronic progressive disease of the joints in which inflammation causes joint destruction and deformity of the joints.  APO-Leflunomide 20 can help slow down the process of joint destruction and improve functional ability and quality of life and is particularly helpful in patients who do not respond to other treatments or if other treatments cannot be used.  Psoriatic arthritis is a form of arthritis that is often also associated with psoriasis of the skin, characterised by raised red patches covered in silvery scales, but can develop before skin symptoms appear.  Psoriatic arthritis differs from rheumatoid arthritis by being negative for rheumatoid factor, a blood test for an antibody that is usually positive in rheumatoid arthritis.  APO-Leflunomide tablets 20mg are used only for treating inflammation of the joints in psoriatic arthritis not for the skin condition alone.  Rheumatoid arthritis and active psoriatic arthritis are both characterised by periods of remission and periods of flare up when symptoms worsen and joints become painful and swollen.  APO-Leflunomide tablets 20mg will not cure arthritic disease but can be used to relieve symptoms of the disease including pain, inflammation, tenderness, stiffness and swelling in the affected joints, and improve the functional use of affected joints. 

How does APO-Leflunomide work?

APO-Leflunomide tablets 20mg contain leflunomide, a disease-modifying antirheumatic drug (DMARD) that is used to relieve inflammatory symptoms of the arthritic diseases rheumatoid arthritis and active psoriatic arthritis.  Leflunomide in APO-Leflunomide tablets 20mg acts as an immunomodulatory drug with immunosuppressive characteristics, which means that it can suppress the immune system by interacting directly with the lymphocytes (white blood cells) involved in the immune response.  Leflunomide in APO-Leflunomide tablets 20mg works by several possible mechanisms.  It is thought to inhibit the production by lymphocytes of inflammatory mediators called cytokines, such as interleukins and prostaglandins, particularly tumour necrosis factor (TNF), interleukin 1 (IL1) and interleukin 6 (IL6).  Leflunomide in APO-Leflunomide tablets also inhibits proliferation of rapidly dividing inflammatory lymphocytes by blocking the action of dihydroorotate dehydrogenase, an enzyme involved in pyrimidine synthesis, which inhibits lymphocyte proliferation, and helps reduce the inflammation that is responsible for the pain and swelling of rheumatic joints.  These actions of leflunomide in APO-Leflunomide tablets 20mg dampen down the immune response by interacting with immune cells that influence the immune response to autoantigens (directed against self) and help reduce progression of the disease and reduce symptoms. 

What does APO-Leflunomide contain?

APO-Leflunomide contains the active ingredient leflunomide 20mg, a disease-modifying antirheumatic drug (DMARD) used to treat rheumatoid arthritis and active psoriatic arthritis.  They also contain lactose, crospovidone, magnesium stearate, and colloidal silicon dioxide.

Treating rheumatic diseases with APO-Leflunomide

APO-Leflunomide tablets 20mg contain leflunomide, a disease-modifying antirheumatic drug (DMARD) that is used to treat rheumatoid arthritis and active psoriatic arthritis, to improve symptoms of the disease, which include pain, inflammation, tenderness, stiffness and swelling in the affected joints.  Rheumatoid arthritis and psoriatic arthritis (a form of arthritis that is often also associated with psoriasis of the skin, causing raised red patches covered in silvery scales) are both autoimmune disorders (when the immune system attacks self) and are characterised by an overactive immune system and a genetic predisposition.  Leflunomide in APO-Leflunomide tablets 20mg is an immunomodulatory drug and acts directly on the lymphocytes (white blood cells) involved in the immune response, by inhibiting the production of cytokines, which are inflammatory mediators.  Also, Leflunomide in APO-Leflunomide tablets 20mg blocks the proliferation of rapidly dividing inflammatory lymphocytes, which helps reduce the inflammation.  APO-Leflunomide 20 can help slow down the process of joint destruction and improve joint function and quality of life, by reducing pain and inflammation but will not cure arthritic disease.

What are the side effects of APO-Leflunomide?

The most commonly reported side effects when taking APO-Leflunomide tablets 20mg include diarrhoea, nausea, vomiting, abdominal pain, stomatitis (oral mucosal disorder) anorexia, weight loss, hair loss, eczema, rash, pruritus (itching), dry skin, mild increase in blood pressure, paraesthesia (tingling of the skin).

When should APO-Leflunomide not be used?

You should not use APO-Leflunomide tablets 20mg if you:

  • are allergic to leflunomide or any ingredients in APO-Leflunomide
  • are pregnant or are breastfeeding
  • have kidney or liver disease
  • have hypoproteinaemia (oedema – water retention, and loss of protein from the blood) such as nephrotic syndrome
  • have reduced immunity or immunodeficiency (such as due to AIDS)
  • have severe uncontrolled infection
  • are taking medicines that interact with APO-Leflunomide, including other immunomodifiers like methotrexate, the anticoagulant warfarin, immunisation with a live vaccine, statins, cholestyramine or activated charcoal for high cholesterol, repaglinide for diabetes, rifampicin for tuberculosis, non-steroidal anti-inflammatories like diclofenac or corticosteroids for inflammation

What medications interact with APO-Leflunomide?

Several medications interact with APO-Leflunomide tablets 20mg and should either not be taken while you are taking APO-Leflunomide or only after discussion and instruction from your doctor:

  • Drugs that cause a serious reaction with APO-Leflunomide: other immunomodifiers like methotrexate could cause liver toxicity, immunisation with a live vaccine, non-steroidal anti-inflammatories like diclofenac or corticosteroids for inflammation
  • Drugs that affect APO-Leflunomide: cholestyramine or activated charcoal for high cholesterol
  • Drugs that are affected by APO-Leflunomide: the anticoagulant warfarin, repaglinide for diabetes, statins for for high cholesterol, rifampicin for tuberculosis

How should APO-Leflunomide be taken?

You should take your APO-Leflunomide tablets 20mg swallowed whole once daily with or without food and at the same time each day.  The dose you take depends on what you are being treated for and you will probably be started on a loading dose (high dose) which will then be reduced after 3 days.  You should start to see a response after 4-6 weeks, with further improvement after 4-6 months.  You should continue to take your APO-Leflunomide tablets 20mg for as long as recommended by your doctor, which may be for several months or longer. 

How long should you take APO-Leflunomide?

You should continue to take your APO-Leflunomide tablets 20mg for as long as recommended by your doctor, which may be for several months or longer. 

Missed dose of APO-Leflunomide

If you miss a dose of APO-Leflunomide tablets 20mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose.  Do not take a double dose.

How should APO-Leflunomide be stored?

You should store your APO-Leflunomide tablets 20mg below 25°C in a cool dry place. 

All medicines have risks and benefits, and individual results may vary. Only purchase medicines from this site in accordance with the advice you have obtained from an appropriate medical professional.
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